Bioceramics and bioglasses are ceramic materials that are biocompatible. Bioceramics are an important subset of biomaterials. Bioceramics range in biocompatibility from the ceramic oxides, which are inert in the body, to the other extreme of resorbable materials, which are eventually replaced by the body after they have assisted
Several peptide hormones are initially synthesized as inactive precursors. It is only on entry of these prohormones and their processing proteases into dense core secretory granules (DCSGs) that the precursors are cleaved to generate their active forms. Prohormone convertase (PC)1/3 is a processing protease that is targeted to DCSGs. The signal for targeting PC1/3 to DCSGs resides in its
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MATERIALS AND METHODS Granule cell preparation BALB/c mice breeding pairs or pregnant rats were obtained from Charles River Laboratories (Wilmington, MA). Pups were saced at various postnatal days by decapitation. Cerebella were placed in calcium
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12/7/2017· A coination of genetically-encoded calcium indiors and micro-optics has enabled monitoring of large-scale dynamics of neuronal activity from behaving animals. In these studies, wide-field microscopy is often used to visualize neural activity. However, this method lacks optical sectioning capability, and therefore its axial resolution is generally poor. At present, it is unclear whether
Depolarization of granule cells enhances calcium entry (more than 3‐fold) via voltage‐sensitive Ca 2+ channels (VSCCs) (Suzuki et al. 2005). This calcium entry activates Ca 2+ –calmodulin‐dependent protein kinase (CaMK) and calcineurin phosphatase (CaN) ( West et al. 2002 ) and mimics signalling mechanisms of developing granule cells.
Starting materials of calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts that were dissolved in appropriate amounts in distilled water were used during powder precipitation runs. The composite bioceramic powders were prepared with compositions of 20%‐90% HA (the balance being the TCP phase) with increments of 10%.
(D) Normalized calcium events and cell maps from LEC FOVs. Example cell responses during exposure to a six-odor panel (20 trials). Normalized Ca event magnitude was generated by dividing each event magnitude by the mean event magnitude across the session and averaged across trials. 4-s odor delivery times are noted below raster, with average responses above trace (mean [black] plus SEM [gray]).
Effects of disruption of the actin cytoskeleton on α-granule and dense granule secretion. (A) Platelets were incubated in the presence of either vehicle (•), 4 μM cytochalasin E ( …
calcium-containing gradients (not shown), but the calcium-dependence of the binding to microsomes was not investigated. 3.2. Relative binding of ‘251-calmodulin to granule andplasma meranes The microfuge assay in [l] was used to
Read "Pharmacological characterisation of voltage‐sensitive calcium channels and neurotransmitter release from mouse cerebellar granule cells in culture, Journal of Neuroscience Research" on DeepDyve, the largest online rental service for scholarly research with
In SBR R3 and R4, with added calcium, granule diameters remained mostly (50% of the observations) within a range of 11 and 12 mm, presenting a smaller size variation and indiing greater stability. Approximately, 86% of the granules formed in a bioreactor with the addition of Mn 2+ had a diameter size in a range of 2.5 and 3.5 mm, whereas less than 58% of those were in the same range without
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Calcium is a fundamental part of any treatment program to reduce osteoporosis-associated fracture risk. The majority of patients treated for osteoporosis are postmenopausal women,1 who often lack sufficient dietary calcium to meet daily requirements.2
Calcium sulfate dihydrate (CSD) cement has been used as bone void filler and antibiotic carrier for many years. However, the main drawback of CSD cement is its brittleness that limits its handling property. Thus, the aim of this study is to fabrie granular CSD
Background . Astragalus was broadly used for treating heart failure (HF) and arrhythmias in East Asia for thousands of years. Astragalus granule (AG), extracted from Astragalus , shows beneficial effect on the treatment of HF in clinical
In this study, the activation of purified human platelets due to their adhesion on glass and TiO 2 in the absence of extracellular calcium was investigated. Differences in α-granule secretion between platelets adhering on the two surfaces were detected by examining the expression and secretion of the α-granule markers P-selectin (CD62P) and β-throoglobulin.
MATERIALS AND METHODS Transverse cerebellar slices (300 mm thick) were cut from 13- to 17-d-old Sprague Dawley rats, as described previously (Llano et al., 1991; Atluri
Ruthenium Red treatment results in the loss of CML38 signal in cytosolic granules, suggesting that calcium is necessary for stress granule association. These results confirm that CML38 is a core hypoxia response calcium sensor protein and suggest that it serves as a potential calcium signaling target within stress granules and other [mRNP]s that accumulate during flooding stress responses.
29/7/2020· Percentage of Participants Who Are Composite Responders Consistency Scores [ Time Frame: 8 week ] Composite responders are defined as participants who met the weekly response criteria for at least 50% of the weeks with diary entries over the …
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Figure 2. Involvement of intracellular calcium stores in the mechanism of action of PACAP38 in cerebellar granule cells.(A–D) Effect of a single appliion of 10 −6 M PACAP38 on the amplitude (A,C) and the area under the curve (B,D) of the [Ca 2+] i response in the absence (black bars) or presence (white bars) of 10 −6 M thapsigargin, a Ca 2+ ATPase inhibitor, or 10 −5 M 2APB, a
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Unintended consequences: Why carbonation can dominate in microscale hydration of calcium silies. Journal of Materials Research 2015, 30 (16) , 2425-2433. DOI: …